Department of Pharmaceutics

Department of Pharmaceutics was established in the year 2007 to strengthen research and training in the area of various pharmaceutical operations. It is one the most versatile disciplines and stalwarts of pharmacy education which facilitates the students to excel in the domain of pharmaceutical product development, thereby delivering exemplary skills to the students along with fostering leadership skills.

The department strives to become a Centre of Excellence in Drug Development including smart novel drug carriers with an objective to develop low cost new drug delivery systems for improved therapeutic benefits.

The department focus on translational research in areas of cancer, alzheimer's, arthritis, tuberculosis, diabetes mellitus, microbial infections and cosmeceuticals and nutraceuticals in association with various universities and pharmaceutical industries.

The core team is involved in mentoring B.Pharm, M.Pharm and PhD Projects including practice schools in align with industrial requisite.

Core competency includes development of advanced nanoformulations such as nanoparticles, liposomes, nanosponges and nanoemulsions to treat unmet chronic illness.

Core Research Area:

1.Nanotechnology and Targeted drug delivery - Formulation development and characterization.

2.Small bio molecules and Lipid based polymeric drug delivery systems.

3.Transdermal drug delivery system.

4.Invitro / invivo correlation studies.

5.Oral bioavailability, synergistic anticancer efficacy and reduced toxicity of drugs.

6.Drug product development and optimization, and pilot plant scale up investigations.

7.Stability studies as per ICH guidelines.

List of Facilities

• Zeta Sizer Nano – Malvern, UK
• HPLC (CFR complaint) – Shimadzu, Japan
• UV-Visible Spectrophotometer, Shimadzu, Japan
• Tablet Punching Machine – Rimek, India
• Tablet Coater – Kalweka, India
• Humidity & Photo Stability Chamber, REMI, India
• Dissolution apparatus with Autosampler – Lab India
• Rapid mixer granulator - Rimek
• Bulk density tester - Electrolab
• Disintegrator Double unit – Lab India
• Dissolution USP apparatus – Lab India
• Multi-purpose Granulation Equipment – Kalweka – Semi Auto
• Brook Field Viscometer with Digital-100cps - Brook field, USA.
• Homogenizer – REMI, India

Center for Excellence in Nanotechnology and Drug Delivery

Overview:

Center for excellence in Nanotechnology and Drug Delivery is a specialized research facility dedicated to advancing the field of nanotechnology in pharmaceutical sciences which is focused on examining, developing and studying the nano-based approaches to enhance drug delivery, improve drug efficacy and address the various challenges of pharmaceutical industry.

The center is involved in various cutting-edge research in nanotechnology to design novel drug delivery systems and nanomedicines including nanocarrier systems capable of delivering drugs to specific target sites in the body, thereby reducing side effects and increasing therapeutic efficacy. Nanotechnology can help overcome biological barriers and enable controlled release of drugs. This includes nanoparticles, liposomes, micelles, nanosuspensions, and other nano-based formulations to improve drug solubility, stability, and targeted delivery.

Activities:

Currently, the centre is working on site-specific strategies for various diseases which includes cancer-targeting, brain-targeting, HIV-targeting.

1.Formulation development: Developing and optimizing formulations of existing drugs using nano-based approaches to improve their bioavailability, efficacy, and patient compliance. Currently our formulation research encompasses optimization of formulations for delivery of drugs through various routes such as oral, transdermal, nasal and rectal.

2.Education and training: Providing training programs, hands-on experience, workshops, and courses to educate researchers, students, and professionals about pharmaceutical nanotechnology

3.Intellectual Property and technology transfer: Assisting researchers in protecting their intellectual property and facilitating the commercialization of innovative nanotechnology-based drug delivery systems.

Contact Details:

Dr. NM Raghavendra

Professor and Principal

Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

M: 09949110836

 

Dr. Wilson B

Professor and HOD

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M: 9482962475

Facility

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Publications:

1.Nanoparticle-based drug delivery across the blood-brain barrier for treating malignant brain glioma Vishwanath Kurawattimath, Barnabas Wilson, Kannoth Mukundan Geetha, Open Nano, 2023 ISSN: 2352-9520. https://www.sciencedirect.com/journal/opennano

2.Statistical bioprocess optimization for enhanced production of a  thermo alkalophilic polygalacturonase (PGase) from Pseudomonas  sp. 13156349 using solid substrate fermentation (SSF) Mary Arpana, Seema S. Rathore, Archana S. Rao, Ajay Nair, Sunil S. More,  Aneesa Fasim, Heliyon 2023 ISSN 2405-8440 https://www.cell.com/heliyon/home

3.Mechanistic insights into the beneficial effects of curcumin on insulin resistance: Opportunities and challenges. Drug Discov Today.  Balakumar P, Venkatesan K, Abdulla Khan N, Raghavendra NM, Venugopal V, Bharathi DR, Fuloria NK. Drug Discov Today 2023 ISSN: 1878-5832 https://www.sciencedirect.com/journal/drug-discovery-today

4.Trans ethosomal hybrid composites of naproxen-sulfapyridine in hydrogel carrier: anti-inflammatory response in complete Freund’s adjuvant induced arthritis rats. Sajeev Kumar Babasahib, Roaddy Well Born & Nulgumnalli Manjunathaiah Raghavendra. Artificial Cells, Nanomedicine, and Biotechnology, 2022, 59, 50-70. https://www.tandfonline.com/doi/full/10.1080/21691401.2022.2047712

5.Development of Novel S PC-3 Gefitinib Lipid Nanoparticles for Effective Drug Delivery in Breast Cancer. Tissue Distribution Studies and Cell Cytotoxicity Analysis. Sujit Nayek, NM Raghavendra, Sajeev Kumar B. Journal of Drug Delivery Science and Technology. 2021, 61, https://www.sciencedirect.com/journal/journal-of-drug-delivery-science-and-technology.

6. Optimization of Parameters for The Design and Evaluation of Fenofibrate Loaded Floating Microspheres by Taguchi Method. Josephine Leno Jenita Joseph. Mahesh AR , Priyanka SAH , Seema S Rathore. Journal of Research in Pharmacy 2023 ISSN : 2630-6344 https://jrespharm.com/search.php DOI:10.29228/jrp.298.

7. Influence of iontophoresis on delivery of NSAID-loaded deformable liposomal dispersions: in vitro and in vivo evaluation : Dr K. Vanaja. Therapeutic Delivery, 2023 ISSN (online): 2041-6008 https://www.future-science.com/journal/tde DOI: 10.4155/tde-2023-0005.

8. Lipid nanoparticles in the development of mRNA vaccines for COVID-19, Journal of Drug Delivery Science and Technology. Wilson B., Geetha K.M. 2022 17732247 https://www.sciencedirect.com/journal/journal-of-drug-delivery-science-and-technology.

9. Formulate and evaluate the herbal bath soap using extracts of three plants having ethnic and dermatological importance in ayurveda, namely  Azadirecta indica, curcuma longa, ocimum tenuiaflorum. Manjula D. Neuroquantology 2022 ISSN 1303-5150.   

10. Lipid nanoparticles in the development of mRNA vaccines for COVID-19 Barnabas Wilson, Kannoth Mukundan Geetha, Journal of Drug Delivery Science and Technology 2022 17732247 https://www.sciencedirect.com/journal/journal-of-drug-delivery-science-and-technology

11. Nanomedicine to deliver biological macromolecules for treating COVID-19 Barnabas Wilson, Kannoth Mukundan Geetha Vaccine 2022 ISSN 2076-393X  

12. Formulation & evaluation of herbal lipstick from Citrullus Lanatus & Curcuma Longa.   K. Sudheer Kumar, Bibudha Ranjan Tripathy, J. Josephine Leno Jenita, Chandra Shekhar Reddy Bonepally, V.T Iswariya, Konatham Teja Kumar Reddy, Neuro Quantology 2022 ISSN 1303-5150  https://www.neuroquantology.com/

13. Natural Polysaccharides: An Overview of their Role in the Development of Microparticles for Stomach Targeting Seema S Rathore, Geetha M, S Ramachandra Setty, Int. J. Pharm. Investigation 2022 Print -2230-973X, Online - 2230-9713 https://www.jpionline.org/index.php/ijpi/article/view/559.

Funding

No.	Name of the PI	Title	Agency	Amount INR	Year
1	Ms. Seema S. Rathore	Design and target of anticancer drug loaded polymeric nanocarriers for breast cancer	DSU	156000	2023
2	Dr. B. Wilson	Development of albumin nano particles of oxaliplatin- an anticancer drug for treating colon cancer	RGUHS	300000	2021
3	Dr. Manjula D		VGST	400000	2010

Ongoing Projects

• Development and evaluation of Nanosponges containing an anticancer drug to treat colon cancer.
• Development of lipid based nanoformulations for topical delivery of pain modulators.
• Formulation and evaluation of topical hydrogel of anti-fungal drug loaded Nanosponges.
• Liposomes loaded with resveratrol in combination with medicinal plant extract: evaluation of wound healing effect.
• Development and evaluation of meloxicam loaded microbeads for colon targeting.
• Preparation and characterization of venlafaxine loaded serum albumin nanoparticles for brain targeting.
• Development and evaluation of antibiotic loaded nanoparticles incorporated gel for Anal fistula.
• Design and evaluation of antiepileptic drug loaded surface modified polymeric nanocarrier.
• Formulation and evaluation of Nanosponges containing clotrimazole loaded hydrogel for topical delivery.
• Formulation, Optimization and characterization of Nano sponge based gel containing gefitinib.
• Formulation and evaluation of Nanoemulsion containing a phytopharmaceutical for the treatment of Alzheimer's disease.
• Formulation, characterization of gefitinib liposomal transdermal drug delivery system and it’s evaluation for skin irritation and pharmacokinetic studies.
• Formulation and Evaluation of bicalutamide nanobeads for treatment of prostate cancer.
• Formulation and evaluation of floating microparticles of an antihyperlipidemic drug.