Department of Pharmaceutical Chemistry

About the Department

• Department of Pharmaceutical Chemistry deals with the drug discovery. With our well-equipped labs, highly talented staff and inquisitive and hardworking students, we strive to go to greater heights with our R&D in the fields of synthetic chemistry, phytochemistry, and analytical chemistry.
• The department focus mainly on design and discovery of new molecules on anticancer, antimicrobial, neuropharmacological disorders, using computational tools. The department regularly organizes national and international conferences/workshops/seminar/symposia to create knowledge in the field and keep updated with the current scenario.

Core Research Area:

Medicinal chemistry research covers all relevant aspects using advance computational tools including,

• Pathobiochemistry of diseases,
• Identification and validation of (emerging) drug targets,
• Structural biology,
• Drugability of targets,
• Drug design approaches,
• Chemogenomics,
• Synthetic chemistry including green chemistry.

Facilities

Name of the Equipments

• EC-TDS Analyser
• pH Analyser
• Potentiometer
• Nephelometer
• Microprocessor Flame Photometer
• Digital weighing Balance
• Ultra Sonic Cleaner
• UV-VIS Spectrophotometer
• Spectrofluorophotometer
• IR Spirit - L (FTIR)
• Dry Box
• Freezer
• Fuming hood
• Distillation unit
• UV chamber
• Hot air oven

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Publications

• Mechanistic insights into the beneficial effects of curcumin on insulin resistance: Opportunities and challenges. Balakumar P, Venkatesan K, Abdulla Khan N, Raghavendra NM, Venugopal V, Bharathi DR, Fuloria NK. Drug Discov Today. 2023, 28, 7. https://www.sciencedirect.com/journal/drug-discovery-today. doi: 10.1016/j.drudis.2023.103627.
• In-Silico Drug Design and ADME Studies Of Substituted 1, 3, 4-Oxadiazole Analogues As Potent Mycobacterial Dpre1
  Enzyme Inhibitors. Rekha S, A Kalpana, Divekar, A Chandrashekhara, S. A Sagar, Vedika Mourya. A Arun. Journal of Pharmaceutical Negative Results. https://www.pnrjournal.com/index.php/home. DOI: https://doi.org/10.47750/pnr.2023.14.S02.329
• In-Vitro antimicrobial activity of methanolic extract from the fruit pulp of syzygium cumini. Anita.A, Poojitha, Pooja .C, Eur. Chem. Bull. https://www.eurchembull.com. https://www.eurchembull.com/uploads/paper
• "A comprehensive review on the wound healing property of neurocalyx calcinus extractanita. "Anita A, Kalpana Divekar, Geetha.K.M, Eur. Chem. Bull. 2023, 12 (Special Issue 1), 1959-1967. https://www.eurchembull.com/ https://www.eurchembull.com/uploads/paper/3f004e5f5f84656a6492462b4f336b45.pdf
• Artificial intelligence in virtual screening: Models versus experiments. Arul Murugan N., Ruba Priya G., Narahari Sastry G., Markidis S. Aging Medicine and Healthcare. 2022;13(4):163-169.  https://www.agingmedhealthc.com/ 10.33879/AMH.134.2021.07069.
• Protective effect of Celastrus Paniculatus Seeds Extract against lipopolysaccharide-induced paw edema in rats. Anitha K.N., Geetha K.M. Journal of Microbiology, Biotechnology and Food Sciences. 2022, 11(6), e4713. https://www.jmbfs.org/ . DOI: 10.55251/jmbfs.4713
• The Hypoglycemic and Hypolipidemic Effect of 5-Naphthalidin-2, 4 Thiazolidinedione derivatives in Alloxan Induced Type II Diabetic Model. Rekha S., Divekar K., Chandrashekhara S. Research Journal of Pharmacy and Technology. :  2022, 15, 4. https://www.rjptonline.org/ . DOI: 10.52711/0974-360X.2022.00250.
• Implementation of quality by design approach for method development and validation: A review. Sowmya H.G., Priya M.G.R., Murugan V. Research Journal of Pharmacy and Technology . 2022, 15, 1, 436-440. https://www.rjptonline.org/ . DOI: 10.52711/0974-360X.2022.00072.
• Quinazolinone-A Biologically Active Scaffold. Rashmi T., Gnana Ruba Priya M., Murugan V. 2022, 15, 1. https://www.rjptonline.org/. DOI: 10.52711/0974-360X.2022.00069.
• Discovery of Novel 1, 2, 4‐Oxadiazolyl Triazole Hybrids as B‐Raf Inhibitors for the Treatment of Melanoma. Chemistry. Divya Pingili, Dr. Prasad Svum, Dr. Nulgumnalli Manjunathaiah Raghavendra. Chemistry Select. 2022, 7, 47, e202204248. https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/slct.202204248.
• A validated stability indicating RP-HPLC method for the estimation of bendamustine hydrochloride for injection. Divekar K, Shilpashree Hb, Premakumari Kb, Murugan V And Rekha S . International journal of biology, pharmacy and allied sciences. 2022, https://www.researchgate.net/publication/361799193_.  10.31032/IJBPAS/2022/11.10.6435.
• Simultaneous estimation of alogliptin benzoate and metformin HCl in pharmaceutical dosage form by HPTLC. KB Premakumari, V Murugan, M Gandhimathi, Kalpana. International journal of biology, pharmacy and allied sciences . 2022, https://www.researchgate.net/ . 10.31032/IJBPAS/2022/11.10.6521.

Funding

• Design, synthesis and Evaluaton of novel isaxozoles as acetylcholinestrase inhibitors in the treatment of Alzheimer’s – Seed Grant, Kalpana D, INR 500000.00, DSU.
• Design, in-silico studies for some novel semisynthetic conjugates of flavonoids to target HER-2 positive breast cancer using machine learning techniques - Gnana Rupa Priya, DSU, 269000.00

Ongoing Projects

• Qualitative and Quantitative Analysis of Impurities in Pharmaceutical drug products using various Analytical techniques like LC-MS/MS and GC-MS/MS
• Evaluation of Extractables and Leachables on Parenteral Products
• Design and synthesis of heterocyclic molecules as Keap1 Inhibitors
• Identification, characterization of chemical constituents present in the extract of Neurocalynx Calcinus for Anti oxidant activity associated with wound healing
• Design, Synthesis, Characterization and evaluation of anticancer activity of some new oxadiazole derivaives
• In-Silico screening, Phytochemical Investigation and Pharmacological evaluation of Macro-algae as possible Neuro-Protectives
• Stability indicating liquid chromatography method development of bulk drug formulation and degradation product by QBD
• Design, Screening, Identification and Synthesis of 1,3,4,- oxadiazole and pyrazole based novel inhibitors og EGFR receptor and their evaluation for anticancer activity
• A Novel study of microencapsulation ofcelecoxib by polymers and binding interactioncelecoxib by polymers and binding interactionstudy using protein and drug interaction technique against neurodegeneration
• Artificial intelligence on drug discovery, design and semisynthetic derivatives of flavonoids for the treatment of breast cancer