Department of Pharmaceutical Analysis

About the Department

Pharmaceutical analysis is a branch of analytical chemistry. It deals with analysis of drugs and pharmaceuticals based on pharmacopoeial methods and newly developed and validated methods.

Research involves developing new method and validation of new drug substances or drug products or developing new method of analysis for food or cosmetics or analyzing the stability of the drug substances or drug formulations or developing new bioanalytical method for the drugs in biological fluids or toxicity of drug substances based on ICH or FDA guidelines.

• The departmental activities are mainly focused on training and handling the modern analytical instruments such as HPLC, HPTLC, Spectrophotometers, Fluorimeter, Flame photometer, etc., by the graduate students and research scholars.
• The principal remit of the department is the discovery, development and application of analytical methods and techniques relevant to Pharmaceutical sciences.
• It has advanced facilities for carrying out qualitative analysis of drugs and pharmaceuticals using sophisticated analytical instruments such as LC-MS, HPLC, HPTLC, IR, UV and Fluorescence spectro-photometer.

Thrust Areas:

• Development and Validation of Analytical and Bioanalytical methods
• Impurity Profiling
• Excipient Analysis

Facilities:

• Sophisticated Instruments
• Shimadzu HPLC System with UV-Vis Detector
• Agilent HPLC System with PDA Detector
• IR Spectrophotometer with Spectrum –X software
• Camag HPTLC System with win CATS software
• Perkin Elmer UV-VIS Spectrophotometer- Lambda 25 model
• Lab India UV-Vis Spectrophotometer
• Fluorimeter
• Flame Photometer
• Analytical balances of varying sensitivities
• Conductivity meter
• Potentiometer - pH meter

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Funding

• Coccinia grandis fruit jelly as possible antihyperlipidemic nutraceutical (Ref/DSU/REG/2022-23/727 dated 22.05.2023). Name of the PI: Dr. P. Sivakami Sundari, DSU, Rs.5,00,000/-.
• Pharmacognostical, Phytochemical approach and antidiarrhoeal activity of seeds of promising plant, Gauzuma ulmifolia Lam.(RGU:Adv.Res.:Proposal-P-172:2015-16 dated: 06-01-2016). Dr. P. Sivakami Sundari, RGUHS, Rs.2,00,000/-
• Design, Synthesis and Evaluation of novel isaxozoles as acetyl cholinestrase inhibitors in the treatment of Alzheimer’s – DSU Seed Grant, INR 500000.00
• Isolation and characterization of novel active principles from Viscum articulatum burn and Viscum Orientale wild for treating epilepsy. RGUHS-2021 (INR 5,00,000).
• Bioactivity guided Isolation & characterization of potent biomolecules for antiasthmatic activity in Calotropis gigantea. VGST-2021 (INR 20,00,000).
• Synthesis, evaluation and formulation of pyrazole derivatives as potential antidepressants. DSU-2023 (INR 5,00,00).
• Evaluation and Formulation of Pyrazole derivatives as potential Antidepressants – Geetha KM. Seed Grant, DSU, (INR 5,00000)
• Design, synthesis and Evaluaton of novel isaxozoles as acetylcholinestrase inhibitors in the treatment of Alzheimer’s – Seed Grant, Kalpana D, INR 500000.00, DSU.
• Design, in-silico studies for some novel semisynthetic conjugates of flavonoids to target HER-2 positive breast cancer using machine learning techniques - Gnana Rupa Priya, DSU, 269000.00

Consultancy Services

Protective effect of Picha Basti in acetic acid induced ulcerative colitis in B6 mice,

PI: DR Geetha KM, INR. 430000.00